human CCAR1 shRNA silencing AAV

Name
AAV-h-CCAR1-shRNA

Cat No
shAAV-204211

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CCAR1.

shAAV-204211

AAV-h-CCAR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CCAR1 (cell division cycle and apoptosis regulator 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CARP-1; cell cycle and apoptosis regulatory protein 1; cell division cycle and apoptosis regulator protein 1; death inducer with SAP domain

Description (eCommerce)

CCAR1 was identified as a perinuclear phosphoprotein that regulates apoptosis signals in response to chemotherapeutic agents. Induction of apoptosis by CCAR1 involves the epidermal growth factor receptor (EGFR), mitogen-activated protein kinase pathway and caspase-9 activation. CARP-1 has also been demonstrated as a suppressor of human breast cancer growth.

Gene ID

55749

Gene Name (eCommerce)

cell division cycle and apoptosis regulator 1

Gene Name (Vector)

cell division cycle and apoptosis regulator 1

Gene Symbol

CCAR1

HGNC ID

HGNC:24236

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3453

ORF Size (bp)

3453 bp

Protein Name (eCommerce)

Cell division cycle and apoptosis regulator protein 1

RefSeq ID

NM_018237

RefSeq Synonyms

NM_018237, NM_001282960, NM_001282959, BC132725, BC130626,

Research Areas

Apoptosis,Cell Cycle,Gene Expression,mRNA Processing,mRNA Splicing,RNA Processing,Spliceosome,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,cell_cycle,genetics,transcription_translation,cell_biology,genetics

Species

human

Target Sentence

CCAR1 was identified as a perinuclear phosphoprotein that regulates apoptosis signals in response to chemotherapeutic agents. Induction of apoptosis by CCAR1 involves the epidermal growth factor receptor (EGFR), mitogen-activated protein kinase pathway and caspase-9 activation. CARP-1 has also been demonstrated as a suppressor of human breast cancer growth.

UniGene ID

Hs.49853

UniProt ID (eCommerce)

Q8IX12

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.