human CBLL1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CBLL1.
shAAV-204167
AAV-h-CBLL1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CBLL1 (Cbl proto-oncogene like 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1; casitas B-lineage lymphoma-transforming sequence-like protein 1; Cbl proto-oncogene like 1, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1; c-Cbl-like protein 1; E3 ubiquitin-protein ligase Hakai; E-cadherin binding protein E7; HAKAI; RING finger protein 188; RING-type E3 ubiquitin transferase Hakai; RNF188
Description (eCommerce)
Hakai is an E3-ubiquitin ligase and an E-cadherin binding protein that plays a role in modulating cell adhesion.
Description (Vector)
CBLL1 encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant.
Gene ID
79872
Gene Name (eCommerce)
Cbl proto-oncogene like 1
Gene Name (Vector)
Cbl proto-oncogene like 1
Gene Symbol
CBLL1
HGNC ID
HGNC:21225
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1473
ORF Size (bp)
1473 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase Hakai
RefSeq ID
NM_024814
RefSeq Synonyms
NM_024814, NM_001284291, BC144176, BC130531, BC130529,
Research Areas
Translational Control,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Hakai is an E3-ubiquitin ligase and an E-cadherin binding protein that plays a role in modulating cell adhesion.
UniGene ID
Hs.592271
UniProt ID (eCommerce)
Q75N03
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.