human CBFA2T2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CBFA2T2.
shAAV-204157
AAV-h-CBFA2T2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CBFA2T2 (CBFA2/RUNX1 translocation partner 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
core-binding factor, runt domain, alpha subunit 2; translocated to, 2; EHT; ETO homolog on chromosome 20; ETO homologous on chromosome 20; MTG8-like protein; MTG8-related protein 1; MTGR1; myeloid translocation gene-related protein 1; myeloid translocation-related protein 1; p85; protein CBFA2T2; ZMYND3
Description (eCommerce)
CBFA2T2 may function in a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). CBFA2T2 may thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. CBF2T2 may be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O43439].
Description (Vector)
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Gene ID
9139
Gene Name (eCommerce)
CBFA2/RUNX1 translocation partner 2
Gene Name (Vector)
CBFA2/RUNX1 translocation partner 2
Gene Symbol
CBFA2T2
HGNC ID
HGNC:1536
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1845
ORF Size (bp)
1845 bp
Protein Name (eCommerce)
Protein CBFA2T2
RefSeq ID
NM_005093
RefSeq Synonyms
NM_005093, NM_001039709, NM_001032999, BC040344, BC015066,
Research Areas
Neurobiology,Neurodevelopment,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology,transcription_translation
Species
human
Target Sentence
CBFA2T2 may function in a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). CBFA2T2 may thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. CBF2T2 may be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O43439].
UniGene ID
Hs.153934
UniProt ID (eCommerce)
O43439
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.