human CAV2 shRNA silencing AAV

Name
AAV-h-CAV2-shRNA

Cat No
shAAV-204149

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CAV2.

shAAV-204149

AAV-h-CAV2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CAV2 (caveolin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CAV

Description (Vector)

CAV2 is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462).

Gene ID

858

Gene Name (Vector)

caveolin 2

Gene Symbol

CAV2

HGNC ID

HGNC:1528

ORF Size (aa)

489

ORF Size (bp)

489 bp

RefSeq ID

NM_001233

RefSeq Synonyms

NM_198212, NM_001233, NM_001206748, NM_001206747, BC005256,

Species

human

UniGene ID

Hs.603096

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.