human CASP8 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CASP8.
shAAV-204123
AAV-h-CASP8-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CASP8 (caspase 8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5
Description (Vector)
CASP8 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
Gene ID
841
Gene Name (Vector)
caspase 8
Gene Symbol
CASP8
HGNC ID
HGNC:1509
ORF Size (aa)
837
ORF Size (bp)
837 bp
RefSeq ID
NM_033356
RefSeq Synonyms
NM_033358, NM_033356, NM_033355, NM_001228, NM_001080125, NM_001080124, BC068050,
Species
human
UniGene ID
Hs.599762
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.