human CASP7 shRNA silencing AAV

Name 
AAV-h-CASP7-shRNA
Cat No 
shAAV-204122
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CASP7.

shAAV-204122
AAV-h-CASP7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CASP7 (caspase 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3
Description (Vector)
CASP7 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
840
Gene Name (Vector)
caspase 7
Gene Symbol
CASP7
HGNC ID
HGNC:1508
ORF Size (aa)
912
ORF Size (bp)
912 bp
RefSeq ID
NM_001227
RefSeq Synonyms
NM_033340, NM_033339, NM_033338, NM_001320911, NM_001267058, NM_001267057, NM_001267056, NM_001227, BC015799,
Species
human
UniGene ID
Hs.9216

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.