human CASP6 shRNA silencing AAV

Name
AAV-h-CASP6-shRNA

Cat No
shAAV-204120

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CASP6.

shAAV-204120

AAV-h-CASP6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CASP6 (caspase 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MCH2

Description (Vector)

CASP6 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms.

Gene ID

839

Gene Name (Vector)

caspase 6

Gene Symbol

CASP6

HGNC ID

HGNC:1507

ORF Size (aa)

882

ORF Size (bp)

882 bp

RefSeq ID

NM_001226

RefSeq Synonyms

NM_032992, NM_001226, BC004460, BC000305,

Species

human

UniGene ID

Hs.654616

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.