human CARD8 shRNA silencing AAV

Name
AAV-h-CARD8-shRNA

Cat No
shAAV-204088

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CARD8.

shAAV-204088

AAV-h-CARD8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CARD8 (caspase recruitment domain family member 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CARDINAL; DACAR; DAKAR; NDPP; NDPP1; TUCAN

Description (Vector)

CARD8 belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene.

Gene ID

22900

Gene Name (Vector)

caspase recruitment domain family member 8

Gene Symbol

CARD8

HGNC ID

HGNC:17057

ORF Size (aa)

1464

ORF Size (bp)

1464 bp

RefSeq ID

NM_014959

RefSeq Synonyms

NM_014959, NM_001184904, NM_001184903, NM_001184902, NM_001184901, NM_001184900, BC056891, BC045539,

Species

human

UniGene ID

Hs.655940

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.