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human CALD1 shRNA silencing AAV

Name 
AAV-h-CALD1-shRNA
Cat No 
shAAV-203965
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CALD1.

shAAV-203965
AAV-h-CALD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CALD1 (caldesmon 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
caldesmon; CDM; HCAD; H-CAD; LCAD; L-CAD; NAG22; testis secretory sperm-binding protein Li 227n
Description (eCommerce)
Caldesmon is a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of caldesmon possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction [taken from NCBI Entrez Gene (Gene ID: 800)].
Description (Vector)
CALD1 encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Gene ID
800
Gene Name (eCommerce)
caldesmon 1
Gene Name (Vector)
caldesmon 1
Gene Symbol
CALD1
HGNC ID
HGNC:1441
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1617
ORF Size (bp)
1617 bp
Protein Name (eCommerce)
Caldesmon
RefSeq ID
NM_004342
RefSeq Synonyms
NM_033157, NM_033140, NM_033139, NM_033138, NM_004342, BC040354,
Research Areas
Cardiovascular,Cytoskeleton,EGFR Signaling,Neurobiology,Signal Transduction
Research Areas (Faceted)
cardiovascular,signal_transduction,cell_biology,neurobiology
Species
human
Target Sentence
Caldesmon is a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of caldesmon possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction [taken from NCBI Entrez Gene (Gene ID: 800)].
UniGene ID
Hs.490203
UniProt ID (eCommerce)
Q05682

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.