human CALCA shRNA silencing AAV

Name 
AAV-h-CALCA-shRNA
Cat No 
shAAV-203951
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CALCA.

shAAV-203951
AAV-h-CALCA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CALCA (calcitonin related polypeptide alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
alpha-type CGRP; CALC1; calcitonin; calcitonin 1; calcitonin gene-related peptide 1; calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha; CGRP; CGRP1; CGRP-I; CT; katacalcin; KC; PCT
Description (eCommerce)
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q99JA0].
Description (Vector)
CALCA encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
796
Gene Name (eCommerce)
calcitonin related polypeptide alpha
Gene Name (Vector)
calcitonin related polypeptide alpha
Gene Symbol
CALCA
HGNC ID
HGNC:1437
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
426
ORF Size (bp)
426 bp
Protein Name (eCommerce)
Calcitonin
RefSeq ID
NM_001741
RefSeq Synonyms
NM_001741, NM_001033953, NM_001033952, BC143562, BC101599, BC093753, BC069778, BC069760, BC069704, BC069684,
Research Areas
Aging,Cardiology,Cardiovascular,GPCR Signaling,Immunology,Neurobiology,Neurodevelopment,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,cardiovascular,signal_transduction,immunology,neurobiology,developmental_biology
Species
human
Target Sentence
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q99JA0].
UniGene ID
Hs.37058
UniProt ID (eCommerce)
P06881

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.