human C9ORF95 shRNA silencing AAV

Name
AAV-h-C9ORF95-shRNA

Cat No
shAAV-203857

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NMRK1.

shAAV-203857

AAV-h-C9ORF95-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NMRK1 (nicotinamide riboside kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

bA235O14.2; C9orf95; NRK1

Description (Vector)

Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 (PubMed 15137942)).(supplied by OMIM, Mar 2008)

Gene ID

54981

Gene Name (Vector)

nicotinamide riboside kinase 1

Gene Symbol

NMRK1

HGNC ID

HGNC:26057

ORF Size (aa)

528

RefSeq ID

NM_017881

RefSeq Synonyms

NM_017881, NM_001330679, NM_001330678, NM_001127603, BC036804, BC001366,

Species

human

UniGene ID

Hs.494186

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.