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human C4BPB shRNA silencing AAV

Name 
AAV-h-C4BPB-shRNA
Cat No 
shAAV-203441
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human C4BPB.

shAAV-203441
AAV-h-C4BPB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human C4BPB (complement component 4 binding protein beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C4BP
Description (Vector)
C4BPB encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
Gene ID
725
Gene Name (Vector)
complement component 4 binding protein beta
Gene Symbol
C4BPB
HGNC ID
HGNC:1328
ORF Size (aa)
756
ORF Size (bp)
756 bp
RefSeq ID
NM_000716
RefSeq Synonyms
NM_001017367, NM_001017366, NM_001017365, NM_001017364, NM_000716, BC005378,
Species
human
UniGene ID
Hs.99886

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.