human C2 shRNA silencing AAV

Name
AAV-h-C2-shRNA

Cat No
shAAV-203152

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human C2.

shAAV-203152

AAV-h-C2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human C2 (complement C2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ARMD14; CO2

Description (Vector)

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.

Gene ID

717

Gene Name (Vector)

complement C2

Gene Symbol

HGNC ID

HGNC:1248

ORF Size (aa)

2259

ORF Size (bp)

2259 bp

RefSeq ID

NM_000063

RefSeq Synonyms

NM_001282459, NM_001282458, NM_001282457, NM_001178063, NM_001145903, NM_000063, BC043484,

Species

human

UniGene ID

Hs.408903

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.