human CYP21A2 Over-expression AAV
This is an AAV expressing Human CYP21A2.
AAV-206460
AAV-h-CYP21A2
Ready-to-use AAV expressing Human CYP21A2 (cytochrome P450 family 21 subfamily A member 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CA21H; CAH1; CPS1; CYP21; CYP21B; P450c21B
Description (Vector)
CYP21A2 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
1589
Gene Name (Vector)
cytochrome P450 family 21 subfamily A member 2
Gene Symbol
CYP21A2
HGNC ID
HGNC:2600
ORF Size (aa)
1488
ORF Size (bp)
1488 bp
RefSeq ID
NM_000500
RefSeq Synonyms
NM_001128590, NM_000500, BC125182, BC125181,
Species
human
UniGene ID
Hs.654479
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.