human C14ORF153 shRNA silencing AAV

Name 
AAV-h-C14ORF153-shRNA
Cat No 
shAAV-202646
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human KLC1.

shAAV-202646
AAV-h-C14ORF153-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KLC1 (kinesin light chain 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
kinesin 2 60/70kDa; kinesin light chain 1; KLC; KLC 1; KNS2; KNS2A; medulloblastoma antigen MU-MB-2.50
Description (eCommerce)
Kinesin light chain 1 (KLC1) is a member of the kinesin light chain family and a subunit of the tetrameric kinesin molecule. Kinesin is an oligomeric complex comprised of two heavy chains and two light chains. Kinesin transports cellular cargo along microtubules in a plus-end direction. The heavy chain functions as the motor, while the light chain functions as an adapter molecule for binding cargo.
Description (Vector)
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named 'kinesin 2', this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined.
Gene ID
3831
Gene Name (eCommerce)
kinesin light chain 1
Gene Name (Vector)
kinesin light chain 1
Gene Symbol
KLC1
HGNC ID
HGNC:6387
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1683
ORF Size (bp)
1683 bp
Protein Name (eCommerce)
Kinesin light chain 1
RefSeq ID
NM_005552
RefSeq Synonyms
NM_182923, NM_005552, NM_001130107, BC008881,
Research Areas
Antigen Processing and Presentation,Cytoskeleton,Host-Virus Interactions,Immunology,Transport
Research Areas (Faceted)
immunology,cell_biology,infectious_disease
Species
human
Target Sentence
Kinesin light chain 1 (KLC1) is a member of the kinesin light chain family and a subunit of the tetrameric kinesin molecule. Kinesin is an oligomeric complex comprised of two heavy chains and two light chains. Kinesin transports cellular cargo along microtubules in a plus-end direction. The heavy chain functions as the motor, while the light chain functions as an adapter molecule for binding cargo.
UniGene ID
Hs.20107
UniProt ID (eCommerce)
Q07866

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.