human C13ORF15 shRNA silencing AAV

Name
AAV-h-C13ORF15-shRNA

Cat No
shAAV-202594

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human RGCC.

shAAV-202594

AAV-h-C13ORF15-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RGCC (regulator of cell cycle). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

bA157L14.2; C13orf15; RGC-32; RGC32

Description (Vector)

RGCC is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression.

Gene ID

28984

Gene Name (Vector)

regulator of cell cycle

Gene Symbol

RGCC

HGNC ID

HGNC:20369

ORF Size (aa)

414

RefSeq ID

NM_014059

RefSeq Synonyms

NM_014059, BC066334,

Species

human

UniGene ID

Hs.507866

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.