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human BRD7 shRNA silencing AAV

Name 
AAV-h-BRD7-shRNA
Cat No 
shAAV-202258
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human BRD7.

shAAV-202258
AAV-h-BRD7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BRD7 (bromodomain containing 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
75 kDa bromodomain protein; BP75; bromodomain-containing protein 7; CELTIX1; NAG4; protein CELTIX-1
Description (eCommerce)
Bromodomain-containing protein 7 was identified in a two-hybrid screen as an interactor of interferon regulatory factor-2 (IRF-2) and called CELTIX1. BRD7 was also identified as a binding partner of disheveled-1 (Dvl-1) and found to play a role in Wnt signaling and the regulation of glycogen synthase kinase 3-beta activity. Recently, BRD7 was identified as a subunit of the polybromo-associated BRG1-associated factor (PBAF) complex and shown to be required for the modulation of transcription in embryonic stem cells.
Description (Vector)
BRD7 encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants.
Gene ID
29117
Gene Name (eCommerce)
bromodomain containing 7
Gene Name (Vector)
bromodomain containing 7
Gene Symbol
BRD7
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1956
ORF Size (bp)
1956 bp
Protein Name (eCommerce)
Bromodomain-containing protein 7
RefSeq ID
NM_013263
RefSeq Synonyms
NM_013263, NM_001173984, BC094706, BC050728,
Research Areas
Cancer,Cell Cycle,Histone Modification,Signal Transduction,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
Bromodomain-containing protein 7 was identified in a two-hybrid screen as an interactor of interferon regulatory factor-2 (IRF-2) and called CELTIX1. BRD7 was also identified as a binding partner of disheveled-1 (Dvl-1) and found to play a role in Wnt signaling and the regulation of glycogen synthase kinase 3-beta activity. Recently, BRD7 was identified as a subunit of the polybromo-associated BRG1-associated factor (PBAF) complex and shown to be required for the modulation of transcription in embryonic stem cells.
UniGene ID
Hs.437894
UniProt ID (eCommerce)
Q9NPI1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.