human BPNT1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human BPNT1.
shAAV-202245
AAV-h-BPNT1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human BPNT1 (3′(2′), 5′-bisphosphate nucleotidase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HEL20; PIP
Description (Vector)
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.
Gene ID
10380
Gene Name (Vector)
3'(2'), 5'-bisphosphate nucleotidase 1
Gene Symbol
BPNT1
HGNC ID
HGNC:1096
ORF Size (aa)
978
ORF Size (bp)
978 bp
RefSeq ID
NM_006085
RefSeq Synonyms
NM_006085, NM_001286151, NM_001286150, NM_001286149, BC017801,
Species
human
UniGene ID
Hs.406134
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.