human BLNK shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human BLNK.
shAAV-202166
AAV-h-BLNK-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human BLNK (B-cell linker). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AGM4; BASH; bca; BLNK-S; LY57; SLP-65; SLP65
Description (Vector)
BLNK encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.
Gene ID
29760
Gene Name (Vector)
B-cell linker
Gene Symbol
BLNK
HGNC ID
HGNC:14211
ORF Size (aa)
1371
ORF Size (bp)
1371 bp
RefSeq ID
NM_013314
RefSeq Synonyms
NM_013314, NM_001258442, NM_001258441, NM_001258440, NM_001114094, BC018906,
Species
human
UniGene ID
Hs.665244
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.