human BCL11B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human BCL11B.
shAAV-202035
AAV-h-BCL11B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human BCL11B (B-cell CLL/lymphoma 11B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATL1; ATL1-alpha; ATL1-beta; ATL1-delta; ATL1-gamma; B-cell CLL/lymphoma 11B; B-cell CLL/lymphoma 11B (zinc finger protein); B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion protein; B-cell lymphoma/leukaemia 11B; B-cell lymphoma/leukemia 11B; BCL-11B; BCL11B/TRDC fusion; COUP-TF-interacting protein 2; CTIP2; CTIP-2; hRit1; hRIT1-alpha; IDDFSTA; IMD49; radiation-induced tumor suppressor gene 1 protein; RIT1; zinc finger protein hRit1 alpha; ZNF856B
Description (eCommerce)
Bcl11b is a zinc-finger transcription factor that is homologous to the proto-oncogene Bcl11a. Bcl11b functions in T-cell development, and as a tumor suppressor, plays a role in T-cell lymphoma pathogenesis. Bcl11b interacts with ARP1, SIRT1, and TFCOUP1 to modulate transcription.
Description (Vector)
BCL11B encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.
Gene ID
64919
Gene Name (eCommerce)
B cell CLL/lymphoma 11B
Gene Name (Vector)
B-cell CLL/lymphoma 11B
Gene Symbol
BCL11B
HGNC ID
HGNC:13222
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2682
ORF Size (bp)
2682 bp
Protein Name (eCommerce)
B-cell lymphoma/leukemia 11B
RefSeq ID
NM_022898
RefSeq Synonyms
NM_138576, NM_022898, NM_001282238, NM_001282237, BC156139,
Research Areas
Apoptosis,Axonogenesis,Immunology,Neurobiology,Neurodevelopment,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,developmental_biology,immunology,neurobiology,transcription_translation
Species
human
Target Sentence
Bcl11b is a zinc-finger transcription factor that is homologous to the proto-oncogene Bcl11a. Bcl11b functions in T-cell development, and as a tumor suppressor, plays a role in T-cell lymphoma pathogenesis. Bcl11b interacts with ARP1, SIRT1, and TFCOUP1 to modulate transcription.
UniGene ID
Hs.709690
UniProt ID (eCommerce)
Q9C0K0
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.