human BAX shRNA silencing AAV

Name
AAV-h-BAX-shRNA

Cat No
shAAV-201986

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human BAX.

shAAV-201986

AAV-h-BAX-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BAX (BCL2 associated X, apoptosis regulator). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BCL2L4

Description (Vector)

BAX belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Gene ID

581

Gene Name (Vector)

BCL2 associated X, apoptosis regulator

Gene Symbol

BAX

HGNC ID

HGNC:959

ORF Size (aa)

579

ORF Size (bp)

579 bp

RefSeq ID

NM_004324

RefSeq Synonyms

NM_138764, NM_138763, NM_138761, NM_004324, NM_001291431, NM_001291430, NM_001291429, NM_001291428, BC014175,

Species

human

UniGene ID

Hs.624291

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.