human ATRIP shRNA silencing AAV

Name
AAV-h-ATRIP-shRNA

Cat No
shAAV-201805

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ATRIP.

shAAV-201805

AAV-h-ATRIP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ATRIP (ATR interacting protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ATM and Rad3-related-interacting protein; ATR-interacting protein

Description (eCommerce)

ATRIP (ATR-interacting protein) forms a complex with the serine-threonine kinase ATR (ataxia-telangiectasia mutated rad-3 related) to function in the DNA damage response. Through its interaction with replication protein A (RPA), ATRIP aids the recruitment of ATR to regions of DNA damage. ATR-ATRIP interacts with and is regulated by Rad17 and the 9-1-1 complexes.

Description (Vector)

ATRIP encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

84126

Gene Name (eCommerce)

ATR interacting protein

Gene Name (Vector)

ATR interacting protein

Gene Symbol

ATRIP

HGNC ID

HGNC:33499

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2295

ORF Size (bp)

2295 bp

Protein Name (eCommerce)

ATR-interacting protein

RefSeq ID

NM_032166

RefSeq Synonyms

NM_130384, NM_032166, NM_001271023, NM_001271022, BC030597, BC020563, BC014153,

Research Areas

Cell Cycle,DNA Damage/Repair,DNA Replication,Fanconi anemia,Homologous Recombination,Replication,Signal Transduction

Research Areas (Faceted)

signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.694840

UniProt ID (eCommerce)

Q8WXE1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.