human ATF7IP shRNA silencing AAV

Name 
AAV-h-ATF7IP-shRNA
Cat No 
shAAV-201629
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ATF7IP.

shAAV-201629
AAV-h-ATF7IP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ATF7IP (activating transcription factor 7 interacting protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
activating transcription factor 7-interacting protein 1; AM; ATF7-interacting protein; ATFa-associated modulator; ATF-interacting protein; ATF-IP; hAM; MBD1-containing chromatin-associated factor 1; MCAF; MCAF1; p621
Description (eCommerce)
MBD1-Containing Chromatin-Associated Factor (MCAF) associates with methyl CpG-binding protein (MBD1) that functions to recruit methyltransferases such as SETDB1 to chromatin. MCAF is required for the transcriptional repression and heterochromatin formation mediated by MBD1 and SETDB1.
Description (Vector)
ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 (PubMed 19106100)).(supplied by OMIM, Nov 2010)
Gene ID
55729
Gene Name (eCommerce)
activating transcription factor 7 interacting protein
Gene Name (Vector)
activating transcription factor 7 interacting protein
Gene Symbol
ATF7IP
HGNC ID
HGNC:20092
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3318
ORF Size (bp)
3318 bp
Protein Name (eCommerce)
Activating transcription factor 7-interacting protein 1
RefSeq ID
NM_018179
RefSeq Synonyms
NM_181352, NM_018179, NM_001286515, NM_001286514, BC063855,
Research Areas
Host-Virus Interactions,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,infectious_disease,transcription_translation
Species
human
Target Sentence
MBD1-Containing Chromatin-Associated Factor (MCAF) associates with methyl CpG-binding protein (MBD1) that functions to recruit methyltransferases such as SETDB1 to chromatin. MCAF is required for the transcriptional repression and heterochromatin formation mediated by MBD1 and SETDB1.
UniGene ID
Hs.714407
UniProt ID (eCommerce)
Q6VMQ6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.