human ATF6 shRNA silencing AAV

Name 
AAV-h-ATF6-shRNA
Cat No 
shAAV-201627
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ATF6.

shAAV-201627
AAV-h-ATF6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ATF6 (activating transcription factor 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ACHM7; Activating transcription factor 6 alpha; ATF6A; ATF6-alpha; cAMP-dependent transcription factor ATF-6 alpha; cyclic AMP-dependent transcription factor ATF-6 alpha
Description (eCommerce)
Activating transcription factor 6 (ATF6) is a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells [taken from NCBI Entrez Gene (Gene ID: 22926)].
Description (Vector)
ATF6 encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. ATF6 is also thought to be a potential therapeutic target for cystic fibrosis.
Gene ID
22926
Gene Name (eCommerce)
activating transcription factor 6
Gene Name (Vector)
activating transcription factor 6
Gene Symbol
ATF6
HGNC ID
HGNC:791
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2013
ORF Size (bp)
2013 bp
Protein Name (eCommerce)
Cyclic AMP-dependent transcription factor ATF-6 alpha
RefSeq ID
NM_007348
RefSeq Synonyms
NM_007348, BC166676, BC014969,
Research Areas
Alzheimer's Disease,Golgi Apparatus,Neurobiology,Neurodegeneration,Protein Folding,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Activating transcription factor 6 (ATF6) is a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells [taken from NCBI Entrez Gene (Gene ID: 22926)].
UniGene ID
Hs.492740
UniProt ID (eCommerce)
P18850

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.