human ASPN shRNA silencing AAV

Name
AAV-h-ASPN-shRNA

Cat No
shAAV-201578

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ASPN.

shAAV-201578

AAV-h-ASPN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ASPN (asporin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

OS3; PLAP-1; PLAP1; SLRR1C

Description (Vector)

ASPN encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.

Gene ID

54829

Gene Name (Vector)

asporin

Gene Symbol

ASPN

HGNC ID

HGNC:14872

ORF Size (aa)

1155

ORF Size (bp)

1155 bp

RefSeq ID

NM_017680

RefSeq Synonyms

NM_017680, NM_001193335, BC063114,

Species

human

UniGene ID

Hs.435655

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.