human ARRB2 shRNA silencing AAV

Name 
AAV-h-ARRB2-shRNA
Cat No 
shAAV-201476
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ARRB2.

shAAV-201476
AAV-h-ARRB2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ARRB2 (arrestin beta 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ARB2; ARR2; arrestin 3; Arrestin beta-2; BARR2; beta-arrestin-2; non-visual arrestin-3
Description (eCommerce)
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Beta-arrestin 2, like beta-arrestin 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for beta-arrestin 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. [taken from NCBI Entrez Gene (Gene ID: 409)].
Gene ID
409
Gene Name (eCommerce)
arrestin beta 2
Gene Name (Vector)
arrestin beta 2
Gene Symbol
ARRB2
HGNC ID
HGNC:712
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1230
ORF Size (bp)
1230 bp
Protein Name (eCommerce)
Beta-arrestin-2
RefSeq ID
NM_004313
RefSeq Synonyms
NM_199004, NM_004313, NM_001330064, NM_001257331, NM_001257330, NM_001257329, NM_001257328, BC067368, BC007427,
Research Areas
Cancer,Cardiology,Cardiovascular,Hedgehog Signaling,Immunology,Interleukin Signaling,MAPK Signaling,Neurobiology,NF-kB Signaling,Notch Signaling,Signal Transduction,TGF-beta Signaling,Toll-like Receptor Signaling,Ubiquitination,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Beta-arrestin 2, like beta-arrestin 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for beta-arrestin 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. [taken from NCBI Entrez Gene (Gene ID: 409)].
UniGene ID
Hs.435811
UniProt ID (eCommerce)
P32121

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.