human ARNTL2 shRNA silencing AAV

Name
AAV-h-ARNTL2-shRNA

Cat No
shAAV-201455

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ARNTL2.

shAAV-201455

AAV-h-ARNTL2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ARNTL2 (aryl hydrocarbon receptor nuclear translocator like 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

bHLHe6; BMAL2; CLIF; MOP9; PASD9

Description (Vector)

ARNTL2 encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene ID

56938

Gene Name (Vector)

aryl hydrocarbon receptor nuclear translocator like 2

Gene Symbol

ARNTL2

HGNC ID

HGNC:18984

ORF Size (aa)

1800

ORF Size (bp)

1800 bp

RefSeq ID

NM_020183

RefSeq Synonyms

NM_020183, NM_001248005, NM_001248004, NM_001248003, NM_001248002, BC125062, BC125061,

Species

human

UniGene ID

Hs.663740

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.