human ARID5B shRNA silencing AAV

Name
AAV-h-ARID5B-shRNA

Cat No
shAAV-201386

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ARID5B.

shAAV-201386

AAV-h-ARID5B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ARID5B (AT-rich interaction domain 5B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DESRT; MRF-2; MRF2

Description (Vector)

ARID5B encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. ARID5B also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

84159

Gene Name (Vector)

AT-rich interaction domain 5B

Gene Symbol

ARID5B

HGNC ID

HGNC:17362

ORF Size (aa)

3564

ORF Size (bp)

3564 bp

RefSeq ID

NM_032199

RefSeq Synonyms

NM_032199, NM_001244638, BC156570, BC152736,

Species

human

UniGene ID

Hs.535297

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.