human ARHGEF6 shRNA silencing AAV

Name 
AAV-h-ARHGEF6-shRNA
Cat No 
shAAV-201373
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ARHGEF6.

shAAV-201373
AAV-h-ARHGEF6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
alphaPIX; alpha-PIX; COOL2; Cool-2; MRX46; PAK-interacting exchange factor alpha; PAK-interacting exchange factor, alpha; PIXA; Rac/Cdc42 guanine exchange factor (GEF) 6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Rac/Cdc42 guanine nucleotide exchange factor 6; rho guanine nucleotide exchange factor 6
Description (eCommerce)
Rho guanine nucleotide exchange factor 6 (ARHGEF6) functions as a guanine nucleotide exchange factor (GEF) for RAC1. ARHGEF6 was originally identified as a binding partner of p21 activated kinase (Pak) and was termed Pix (Pak interactive exchange factor).
Description (Vector)
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.
Gene ID
9459
Gene Name (eCommerce)
Rac/Cdc42 guanine nucleotide exchange factor 6
Gene Name (Vector)
Rac/Cdc42 guanine nucleotide exchange factor 6
Gene Symbol
ARHGEF6
HGNC ID
HGNC:685
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2331
ORF Size (bp)
2331 bp
Protein Name (eCommerce)
Rho guanine nucleotide exchange factor 6
RefSeq ID
NM_004840
RefSeq Synonyms
NM_004840, NM_001306177, BC043505, BC039856,
Research Areas
Apoptosis,Cancer,Cytoskeleton,GPCR Signaling,Immunology,Neurobiology,Neurodevelopment,NGF Signaling,PDGF Signaling,Rho Signaling,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,immunology,neurobiology,developmental_biology,signal_transduction,immunology
Species
human
Target Sentence
Rho guanine nucleotide exchange factor 6 (ARHGEF6) functions as a guanine nucleotide exchange factor (GEF) for RAC1. ARHGEF6 was originally identified as a binding partner of p21 activated kinase (Pak) and was termed Pix (Pak interactive exchange factor).
UniGene ID
Hs.522795
UniProt ID (eCommerce)
Q15052

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.