human ARHGEF3 shRNA silencing AAV

Name
AAV-h-ARHGEF3-shRNA

Cat No
shAAV-201368

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ARHGEF3.

shAAV-201368

AAV-h-ARHGEF3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ARHGEF3 (Rho guanine nucleotide exchange factor 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GEF3; STA3; XPLN

Description (Vector)

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

50650

Gene Name (Vector)

Rho guanine nucleotide exchange factor 3

Gene Symbol

ARHGEF3

HGNC ID

HGNC:683

ORF Size (aa)

975

RefSeq ID

NM_019555

RefSeq Synonyms

NM_019555, NM_001289698, NM_001128616, NM_001128615, BC104723, BC099715, BC098272, BC098122, BC054345,

Species

human

UniGene ID

Hs.476402

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.