human AREG shRNA silencing AAV

Name
AAV-h-AREG-shRNA

Cat No
shAAV-201262

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human AREG.

shAAV-201262

AAV-h-AREG-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AREG (amphiregulin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AR; AREGB; CRDGF; SDGF

Description (Vector)

AREG is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.

Gene ID

374

Gene Name (Vector)

amphiregulin

Gene Symbol

AREG

HGNC ID

HGNC:651

ORF Size (aa)

759

ORF Size (bp)

759 bp

RefSeq ID

NM_001657

RefSeq Synonyms

NM_001657, BC146967, BC146953, BC009799,

Species

human

UniGene ID

Hs.270833

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.