human APOL3 shRNA silencing AAV

Name
AAV-h-APOL3-shRNA

Cat No
shAAV-201209

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human APOL3.

shAAV-201209

AAV-h-APOL3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human APOL3 (apolipoprotein L3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

apoL-III; APOLIII; CG121; CG12_1

Description (Vector)

APOL3 is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 6. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants.

Gene ID

80833

Gene Name (Vector)

apolipoprotein L3

Gene Symbol

APOL3

HGNC ID

HGNC:14868

ORF Size (aa)

996

ORF Size (bp)

996 bp

RefSeq ID

NM_145641

RefSeq Synonyms

NM_145642, NM_145641, NM_145640, NM_145639, NM_030644, NM_014349, BC050596, BC042918,

Species

human

UniGene ID

Hs.474737

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.