human APLP2 shRNA silencing AAV

Name
AAV-h-APLP2-shRNA

Cat No
shAAV-201160

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human APLP2.

shAAV-201160

AAV-h-APLP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human APLP2 (amyloid beta precursor like protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

APLP-2; APPH; APPL2; CDEBP

Description (Vector)

APLP2 encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID

334

Gene Name (Vector)

amyloid beta precursor like protein 2

Gene Symbol

APLP2

HGNC ID

HGNC:598

ORF Size (aa)

1569

ORF Size (bp)

1569 bp

RefSeq ID

NM_001642

RefSeq Synonyms

NM_001642, NM_001328686, NM_001328685, NM_001328684, NM_001328682, NM_001243299, NM_001142278, NM_001142277, NM_001142276, BC004371, BC000373,

Species

human

UniGene ID

Hs.709184

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.