human APLP1 shRNA silencing AAV

Name
AAV-h-APLP1-shRNA

Cat No
shAAV-201158

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human APLP1.

shAAV-201158

AAV-h-APLP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human APLP1 (amyloid beta precursor like protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

APLP

Description (Vector)

APLP1 encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene ID

333

Gene Name (Vector)

amyloid beta precursor like protein 1

Gene Symbol

APLP1

HGNC ID

HGNC:597

ORF Size (aa)

1953

ORF Size (bp)

1953 bp

RefSeq ID

NM_005166

RefSeq Synonyms

NM_005166, NM_001024807, BC012889,

Species

human

UniGene ID

Hs.74565

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.