human AP2A1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human AP2A1.
shAAV-201089
AAV-h-AP2A1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human AP2A1 (adaptor related protein complex 2 alpha 1 subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
100 kDa coated vesicle protein A; adapter-related protein complex 2 alpha-1 subunit; adapter-related protein complex 2 subunit alpha-1; adaptin, alpha A; adaptor protein complex AP-2 subunit alpha-1; adaptor related protein complex 2 alpha 1 subunit; Adaptor-related protein complex 2 subunit alpha-1; ADTAA; alpha1-adaptin; alpha-adaptin A; AP-2 complex subunit alpha-1; AP2-ALPHA; CLAPA1; clathrin assembly protein complex 2 alpha-A large chain; clathrin-associated/assembly/adaptor protein, large, alpha 1; plasma membrane adaptor HA2/AP2 adaptin alpha A subunit
Description (eCommerce)
Alpha-adaptin A is a subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles [taken from NCBI Entrez Gene (Gene ID: 160)].
Description (Vector)
AP2A1 encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined.
Gene ID
160
Gene Name (eCommerce)
adaptor related protein complex 2 subunit alpha 1
Gene Name (Vector)
adaptor related protein complex 2 alpha 1 subunit
Gene Symbol
AP2A1
HGNC ID
HGNC:561
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2949
ORF Size (bp)
2949 bp
Protein Name (eCommerce)
AP-2 complex subunit alpha-1
RefSeq ID
NM_014203
RefSeq Synonyms
NM_130787, NM_014203, BC014214,
Research Areas
Antigen Processing and Presentation,Axon Guidance,Cancer,EGFR Signaling,EGFR Signaling in Cancer,Golgi Apparatus,Host-Virus Interactions,Huntington's Disease,Immunology,Neurobiology,Neurodegeneration,NGF Signaling,Signal Transduction,Transport
Research Areas (Faceted)
cancer,cell_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
Alpha-adaptin A is a subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles [taken from NCBI Entrez Gene (Gene ID: 160)].
UniGene ID
Hs.467125
UniProt ID (eCommerce)
O95782
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.