human ANXA5 shRNA silencing AAV

Name 
AAV-h-ANXA5-shRNA
Cat No 
shAAV-201057
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ANXA5.

shAAV-201057
AAV-h-ANXA5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ANXA5 (annexin A5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
anchorin CII; annexin A5; annexin V; annexin-5; ANX5; calphobindin I; CBP-I; endonexin II; ENX2; epididymis secretory protein Li 7; HEL-S-7; lipocortin V; PAP-I; placental anticoagulant protein 4; placental anticoagulant protein I; PP4; RPRGL3; thromboplastin inhibitor; VAC-alpha; vascular anticoagulant-alpha
Description (eCommerce)
Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P08758].
Description (Vector)
ANXA5 belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.
Gene ID
308
Gene Name (eCommerce)
annexin A5
Gene Name (Vector)
annexin A5
Gene Symbol
ANXA5
HGNC ID
HGNC:543
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
963
ORF Size (bp)
963 bp
Protein Name (eCommerce)
Annexin A5
RefSeq ID
NM_001154
RefSeq Synonyms
NM_001154, BC018671, BC012822, BC012804, BC004993, BC001429,
Research Areas
Apoptosis,Cardiovascular,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,cardiovascular
Species
human
Target Sentence
Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P08758].
UniGene ID
Hs.705884
UniProt ID (eCommerce)
P08758

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.