human AKR7A2 shRNA silencing AAV

Name
AAV-h-AKR7A2-shRNA

Cat No
shAAV-200694

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human AKR7A2.

shAAV-200694

AAV-h-AKR7A2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AKR7A2 (aldo-keto reductase family 7 member A2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AFAR; AFAR1; AFB1-AR1; AKR7

Description (Vector)

AKR7A2 belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde.

Gene ID

8574

Gene Name (Vector)

aldo-keto reductase family 7 member A2

Gene Symbol

AKR7A2

HGNC ID

HGNC:389

ORF Size (aa)

993

ORF Size (bp)

993 bp

RefSeq ID

NM_003689

RefSeq Synonyms

NM_003689, NM_001320979, BC013996, BC012171, BC011586, BC010852, BC004111,

Species

human

UniGene ID

Hs.571886

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.