human AIRE shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human AIRE.
shAAV-200631
AAV-h-AIRE-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human AIRE (autoimmune regulator). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AIRE1; APECED; APS1; APSI; PGA1;
Description (Vector)
AIRE encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
Gene ID
326
Gene Name (Vector)
autoimmune regulator
Gene Symbol
AIRE
HGNC ID
HGNC:360
ORF Size (aa)
1047
ORF Size (bp)
1047 bp
RefSeq ID
NM_000383
RefSeq Synonyms
NM_000658, NM_000383, BC137270, BC137268,
Species
human
UniGene ID
Hs.129829
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.