human AGTR2 shRNA silencing AAV

Name
AAV-h-AGTR2-shRNA

Cat No
shAAV-200583

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human AGTR2.

shAAV-200583

AAV-h-AGTR2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AGTR2 (angiotensin II receptor type 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AT2; ATGR2; MRX88

Description (Vector)

AGTR2 belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation.

Gene ID

186

Gene Name (Vector)

angiotensin II receptor type 2

Gene Symbol

AGTR2

HGNC ID

HGNC:338

ORF Size (aa)

1092

ORF Size (bp)

1092 bp

RefSeq ID

NM_000686

RefSeq Synonyms

NM_000686, BC095504,

Species

human

UniGene ID

Hs.405348

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.