human AGFG2 shRNA silencing AAV

Name
AAV-h-AGFG2-shRNA

Cat No
shAAV-200558

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human AGFG2.

shAAV-200558

AAV-h-AGFG2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AGFG2 (ArfGAP with FG repeats 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HRBL; RABR

Description (Vector)

AGFG2 is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. The 3' UTR of this gene contains an insulin receptor substrate 3-like pseudogene.

Gene ID

3268

Gene Name (Vector)

ArfGAP with FG repeats 2

Gene Symbol

AGFG2

HGNC ID

HGNC:5177

ORF Size (aa)

1446

ORF Size (bp)

1446 bp

RefSeq ID

NM_006076

RefSeq Synonyms

NM_006076, BC017329,

Species

human

UniGene ID

Hs.521083

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.