human ADARB1 shRNA silencing AAV

Name
AAV-h-ADARB1-shRNA

Cat No
shAAV-200407

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ADARB1.

shAAV-200407

AAV-h-ADARB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ADARB1 (adenosine deaminase, RNA specific B1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ADAR2; DRABA2; DRADA2; RED1

Description (Vector)

ADARB1 encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.

Gene ID

104

Gene Name (Vector)

adenosine deaminase, RNA specific B1

Gene Symbol

ADARB1

HGNC ID

HGNC:226

ORF Size (aa)

2106

ORF Size (bp)

2106 bp

RefSeq ID

NM_001112

RefSeq Synonyms

NM_015834, NM_015833, NM_001346688, NM_001346687, NM_001160230, NM_001112, BC065545,

Species

human

UniGene ID

Hs.474018

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.