human ADAMTS5 shRNA silencing AAV

Name
AAV-h-ADAMTS5-shRNA

Cat No
shAAV-200390

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ADAMTS5.

shAAV-200390

AAV-h-ADAMTS5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ADAM-TS 11; ADAM-TS 5; ADAM-TS5; ADAMTS-11; ADAMTS-5; ADAMTS11; ADMP-2

Description (Vector)

ADAMTS5 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.

Gene ID

11096

Gene Name (Vector)

ADAM metallopeptidase with thrombospondin type 1 motif 5

Gene Symbol

ADAMTS5

HGNC ID

HGNC:221

ORF Size (aa)

2793

ORF Size (bp)

2793 bp

RefSeq ID

NM_007038

RefSeq Synonyms

NM_007038, BC093777, BC093775,

Species

human

UniGene ID

Hs.58324

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.