human ADAMTS1 shRNA silencing AAV

Name
AAV-h-ADAMTS1-shRNA

Cat No
shAAV-200377

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ADAMTS1.

shAAV-200377

AAV-h-ADAMTS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C3-C5; METH1

Description (Vector)

ADAMTS1 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. ADAMTS1 is likely to be necessary for normal growth, fertility, and organ morphology and function.

Gene ID

9510

Gene Name (Vector)

ADAM metallopeptidase with thrombospondin type 1 motif 1

Gene Symbol

ADAMTS1

HGNC ID

HGNC:217

ORF Size (aa)

2904

ORF Size (bp)

2904 bp

RefSeq ID

NM_006988

RefSeq Synonyms

NM_006988, BC036515,

Species

human

UniGene ID

Hs.643357

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.