human ACVR2A shRNA silencing AAV

Name
AAV-h-ACVR2A-shRNA

Cat No
shAAV-200326

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ACVR2A.

shAAV-200326

AAV-h-ACVR2A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ACVR2A (activin A receptor type 2A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ACTRII; ACVR2

Description (Vector)

ACVR2A encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

Gene ID

Gene Name (Vector)

activin A receptor type 2A

Gene Symbol

ACVR2A

HGNC ID

HGNC:173

ORF Size (aa)

1542

ORF Size (bp)

1542 bp

RefSeq ID

NM_001616

RefSeq Synonyms

NM_001616, NM_001278580, NM_001278579, BC069707, BC067418, BC067417,

Species

human

UniGene ID

Hs.470174

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.