human ACTR1A shRNA silencing AAV

Name
AAV-h-ACTR1A-shRNA

Cat No
shAAV-200307

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ACTR1A.

shAAV-200307

AAV-h-ACTR1A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ACTR1A (ARP1 actin-related protein 1 homolog A, centractin alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ARP1; Arp1A; CTRN1

Description (Vector)

ACTR1A encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin.

Gene ID

10121

Gene Name (Vector)

ARP1 actin-related protein 1 homolog A, centractin alpha

Gene Symbol

ACTR1A

HGNC ID

HGNC:167

ORF Size (aa)

1131

ORF Size (bp)

1131 bp

RefSeq ID

NM_005736

RefSeq Synonyms

NM_005736, BC026016, BC000693,

Species

human

UniGene ID

Hs.153961

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.