human ACSL5 shRNA silencing AAV

Name
AAV-h-ACSL5-shRNA

Cat No
shAAV-200252

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ACSL5.

shAAV-200252

AAV-h-ACSL5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ACSL5 (acyl-CoA synthetase long-chain family member 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ACS2; ACS5; FACL5

Description (Vector)

ACSL5 is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene.

Gene ID

51703

Gene Name (Vector)

acyl-CoA synthetase long-chain family member 5

Gene Symbol

ACSL5

HGNC ID

HGNC:16526

ORF Size (aa)

2220

ORF Size (bp)

2220 bp

RefSeq ID

NM_016234

RefSeq Synonyms

NM_203380, NM_203379, NM_016234, BC007985,

Species

human

UniGene ID

Hs.11638

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.