human ACR shRNA silencing AAV

Name
AAV-h-ACR-shRNA

Cat No
shAAV-200238

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ACR.

shAAV-200238

AAV-h-ACR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ACR (acrosin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids.

Gene ID

Gene Name (Vector)

acrosin

Gene Symbol

ACR

HGNC ID

HGNC:126

ORF Size (aa)

1266

ORF Size (bp)

1266 bp

RefSeq ID

NM_001097

RefSeq Synonyms

NM_001097, BC111593,

Species

human

UniGene ID

Hs.370870

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.