human ACADM shRNA silencing AAV

Name
AAV-h-ACADM-shRNA

Cat No
shAAV-200156

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ACADM.

shAAV-200156

AAV-h-ACADM-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ACADM (acyl-CoA dehydrogenase, C-4 to C-12 straight chain). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ACAD1; MCAD; MCADH

Description (Vector)

ACADM encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

Gene Name (Vector)

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

Gene Symbol

ACADM

HGNC ID

HGNC:89

ORF Size (aa)

1266

ORF Size (bp)

1266 bp

RefSeq ID

NM_000016

RefSeq Synonyms

NM_001286044, NM_001286043, NM_001286042, NM_001127328, NM_000016, BC005377,

Species

human

UniGene ID

Hs.445040

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.