mouse RFWD3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Rfwd3.
shADV-270440
Ad-m-RFWD3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Rfwd3 (ring finger and WD repeat domain 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BC027246
Description (Vector)
E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.
Gene ID
234736
Gene Name (Vector)
ring finger and WD repeat domain 3
Gene Symbol
Rfwd3
ORF Size (aa)
2325
ORF Size (bp)
2325 bp
RefSeq ID
NM_146218
RefSeq Synonyms
NM_146218, BC096602, BC027246, BC023694, BC018533,
Species
mouse
UniGene ID
Mm.334816
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.