mouse FGFR1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Fgfr1.
shADV-259390
Ad-m-FGFR1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Fgfr1 (fibroblast growth factor receptor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW208770; bFGF-R-1; c-fgr; Eask; Fgfr-1; FGFR-I; FLG; Flt-2; Hspy; MFR
Description (Vector)
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
Gene ID
14182
Gene Name (Vector)
fibroblast growth factor receptor 1
Gene Symbol
Fgfr1
ORF Size (aa)
2196
ORF Size (bp)
2196 bp
RefSeq ID
NM_010206
RefSeq Synonyms
NM_010206, NM_001079909, NM_001079908, BC033447, BC010200,
Species
mouse
UniGene ID
Mm.265716
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.